Anti-Hyperlipidemic Effect of Methanol Seed Kernel Extract of Mangifera indica on Wistar Rat Model

The aim of this study was to evaluate the anti-hyperlipidemic effect methanol Mangifera indica seed kernel extract on hyperlipidemic Wistar rats. Mango kernels were dried at room temperature before being ground into fine powder. 500 g mango powder soaked in mL 98 % and shaken intermittently for 72 h, after which concentrated. Twenty five adult male wistar rats divided groups each. Group I: administered 2 ml distilled water. Groups II-V induced hyperlipidemia. However, while II not treated with (negative control), III IV 150 350 mg/kg body weight (MSKE) V standard drug (atorvastatin). Treatment lasted 21 days, sacrificed blood sample collected subsequently analyzed via procedures. Hyperlipidemia characterized by increased levels total cholesterol Low Density Lipoprotein (LDL). Oral administration MSKE significantly (P<0.05) reduced aforementioned indices though higher than that reported normal control group. On other hand, it observed high density lipoprotein (HDL) triacylglyceride (TG) negative (Group II) low but following oral a dose dependent manner. It also M. In conclusion, can be deduced from has potential address hyperlipidemia